Personalized Versus Protocolized Fluid Management Using Noninvasive Hemodynamic Monitoring (Clearsight System) in Patients Undergoing Moderate-Risk Abdominal Surgery

Anesth Analg. 2019 Jul;129(1):e8-e12. doi: 10.1213/ANE.0000000000003553.

Abstract

Advances in noninvasive hemodynamic monitoring systems allow delivery of goal-directed fluid therapy and could therefore be used in less-invasive surgical procedures. In this randomized controlled trial, we compared closed-loop-assisted goal-directed fluid therapy using a noninvasive cardiac output (Clearsight system) monitor (personalized approach) to a protocolized fluid therapy approach in 40 patients undergoing moderate-risk laparoscopic abdominal surgery. Cardiac output and stroke volume variations were not significantly different in both groups and remained within predefined target values >90% of the study time. Personalized fluid therapy does not seem to offer any hemodynamic advantage over a protocolized approach in this population.

Trial registration: ClinicalTrials.gov NCT03039946.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdomen / surgery*
  • Arterial Pressure
  • Belgium
  • Cardiac Output
  • Clinical Protocols*
  • Fluid Therapy / adverse effects
  • Fluid Therapy / methods*
  • Heart Rate
  • Hemodynamic Monitoring / methods*
  • Hemodynamics*
  • Humans
  • Laparoscopy* / adverse effects
  • Monitoring, Intraoperative / methods*
  • Patient-Centered Care*
  • Risk Factors
  • Treatment Outcome

Associated data

  • ClinicalTrials.gov/NCT03039946