This article includes data from the research article entitled "The most painful site of maxillary anterior infiltrations" (Sharifi et al., 2016) [1]. This article presents data of a study regarding pain from infiltration injection in the anterior region of maxilla in 3 locations in the buccal mucosa: the central and lateral incisors' region as well as the canine region. Pain measurements were performed using the Visual Analogue Scale (VAS) at the time of needle insertion, as well as during injection of the anesthetic agent at 5, 30 and 55 s. The injectable agent included 1.8 ml lidocaine 2% with 1:80000 epinephrine.