Evaluation of the Bactericidal Activity of Plazomicin and Comparators against Multidrug-Resistant Enterobacteriaceae

Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00236-18. doi: 10.1128/AAC.00236-18. Print 2018 Aug.

Abstract

The next-generation aminoglycoside plazomicin, in development for infections due to multidrug-resistant (MDR) Enterobacteriaceae, was evaluated alongside comparators for bactericidal activity in minimum bactericidal concentration (MBC) and time-kill (TK) assays against MDR Enterobacteriaceae isolates with characterized aminoglycoside and β-lactam resistance mechanisms. Overall, plazomicin and colistin were the most potent, with plazomicin demonstrating an MBC50/90 of 0.5/4 μg/ml and sustained 3-log10 kill against MDR Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp.

Keywords: Enterobacteriaceae; bactericidal; bactericidal activity; multidrug resistance; plazomicin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides / pharmacology
  • Anti-Bacterial Agents / pharmacology*
  • Carbapenems / pharmacology
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Drug Resistance, Multiple, Bacterial / genetics
  • Enterobacter / drug effects*
  • Enterobacter / genetics
  • Enterobacter / growth & development
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli / growth & development
  • Fluoroquinolones / pharmacology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / growth & development
  • Microbial Sensitivity Tests
  • Polymyxins / pharmacology
  • Sisomicin / analogs & derivatives*
  • Sisomicin / pharmacology
  • Tetracyclines / pharmacology

Substances

  • Aminoglycosides
  • Anti-Bacterial Agents
  • Carbapenems
  • Fluoroquinolones
  • Polymyxins
  • Tetracyclines
  • plazomicin
  • Sisomicin