Peptide-Mediated Neurotransmission Takes Center Stage

Trends Neurosci. 2018 Jun;41(6):325-327. doi: 10.1016/j.tins.2018.03.013.

Abstract

Today, we understand peptide transmitters to be signaling molecules that modulate neural activity. However, in 1982 little was known about neuropeptides and their role in neural communication. The influential 1982 paper by Jan and Jan reported definitive evidence that a presynaptically released neuropeptide evokes postsynaptic responses in an identified cholinergic synapse, thereby fueling a new era in neuroscience.

Keywords: LHRH; neuropeptides; neurotransmission; peptide transmitters; signaling molecules.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Neuropeptides / metabolism
  • Neuropeptides / pharmacology*
  • Presynaptic Terminals / drug effects*
  • Presynaptic Terminals / metabolism*
  • Synaptic Transmission / drug effects*
  • Synaptic Transmission / physiology

Substances

  • Neuropeptides