18F-choline PET/MRI in suspected recurrence of prostate carcinoma

Abstract

Objective: To evaluate the usefulness of simultaneous ¹⁸F-choline PET/MRI in the suspicion of prostate cancer recurrence and to relate ¹⁸F-choline PET/MRI detection rate with analytical and pathological variables.

Material and methods: 27 patients with prostate cancer who received local therapy as primary treatment underwent a ¹⁸F-choline PET/MRI due to suspicion of recurrence (persistently rising serum PSA level). ¹⁸F-choline PET/MRI findings were validated by anatomopathological analysis, other imaging tests or by biochemical response to oncological treatment.

Results: ¹⁸F-choline PET/MRI detected disease in 15 of 27 patients (detection rate 55.56%). 4 (15%) presented exclusively local recurrence, 5 (18%) lymph node metastases and 7 (26%) bone metastases. Mean PSA (PSA_med) at study time was 2.94ng/mL (range 0.18-10ng/mL). PSA_med in patients with positive PET/MRI was 3.70ng/mL (range 0.24-10ng/mL), higher than in patients with negative PET/MRI, PSA_med 1.97ng/mL (range 0.18-4.38ng/mL), although without statistically significant differences. Gleason score at diagnosis in patients with a positive study was 7.33 (range 6-9) and in patients with a negative study was 7 (range 6-9), without statistically significant differences.

Conclusion: ¹⁸F-choline PET/MRI detection rate was considerable despite the relatively low PSA values in our sample. The influence of Gleason score and PSA level on ¹⁸F-choline PET/MRI detection rate was not statistically significant.

Keywords: Choline; Colina; Cáncer de próstata; PET/MRI; PET/RM; Prostate cancer; Recurrence; Recurrencia.