Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters

MeSH terms

• ATP-Binding Cassette Transporters / metabolism
• Acute Kidney Injury / chemically induced
• Adult
• Agranulocytosis / chemically induced
• Antimetabolites, Antineoplastic / administration & dosage
• Antimetabolites, Antineoplastic / adverse effects*
• Biological Transport
• Chemical and Drug Induced Liver Injury / etiology
• Humans
• Male
• Methotrexate / administration & dosage
• Methotrexate / adverse effects*
• Pharmacogenetics*
• Posterior Leukoencephalopathy Syndrome / chemically induced
• Solute Carrier Proteins / metabolism