Development of Diagnostic SNP Markers To Monitor Hybridization Between Sika Deer (Cervus nippon) and Wapiti (Cervus elaphus)

G3 (Bethesda). 2018 Jul 2;8(7):2173-2179. doi: 10.1534/g3.118.200417.

Abstract

Sika deer (Cervus Nippon) and wapiti (Cervus elaphus) are closely related species and their hybridization can result in significant allele-shift of their gene pool. Additive genetic effects and putative heterotic effects of their hybridization on growth performance could confer considerable economic advantage in deer farming. Here, we used double-digest restriction site-associated DNA sequencing technology (ddRAD-seq) and detected ∼320,000 genome-wide SNPs from 30 captive individuals: 7 sika deer, 6 wapiti and 17 F1 hybrids (reciprocal cross). By screening observed heterozygosity of each SNP across four taxonomic groups, we report for the first time a resource of 2,015 putative diagnostic SNP markers (species-specific SNPs for sika deer and wapiti), which can be used to design tools for assessing or monitoring the degree of hybridization between sika deer and wapiti. These ddRAD-seq data and SNP datasets are also valuable resources for genome-wide studies, including trait discovery for breeders of domestic deer.

Keywords: SNP discovery; STACKS software; ddRAD-seq; hybridization; sika deer; wapiti.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Deer / genetics*
  • Genetic Markers*
  • Genetic Variation
  • Genetics, Population
  • Genome
  • Genomics / methods
  • High-Throughput Nucleotide Sequencing
  • Hybridization, Genetic*
  • Polymorphism, Single Nucleotide*
  • Species Specificity

Substances

  • Genetic Markers