Tuberculous meningitis: a roadmap for advancing basic and translational research

Sanjay K Jain; David M Tobin; Elizabeth W Tucker; Vishwanath Venketaraman; Alvaro A Ordonez; Lakshmi Jayashankar; Omar K Siddiqi; Dima A Hammoud; Nemani V Prasadarao; Matyas Sandor; Richard Hafner; Zsuzsanna Fabry; NIH Tuberculous Meningitis Writing Group

doi:10.1038/s41590-018-0119-x

Tuberculous meningitis: a roadmap for advancing basic and translational research

Nat Immunol. 2018 Jun;19(6):521-525. doi: 10.1038/s41590-018-0119-x.

Authors

Sanjay K Jain^{1

2

3}, David M Tobin⁴, Elizabeth W Tucker^{5

6

7}, Vishwanath Venketaraman⁸, Alvaro A Ordonez^{5

6

9}, Lakshmi Jayashankar¹⁰, Omar K Siddiqi^{11

12}, Dima A Hammoud¹³, Nemani V Prasadarao¹⁴, Matyas Sandor¹⁵, Richard Hafner¹⁶, Zsuzsanna Fabry¹⁷; NIH Tuberculous Meningitis Writing Group

Affiliations

¹ Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.
² Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.
³ Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. sjain5@jhmi.edu.
⁴ Departments of Molecular Genetics and Microbiology and of Immunology, Duke University School of Medicine, Durham, NC, USA.
⁵ Center for Tuberculosis Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁶ Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁷ Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁸ Department of Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, USA.
⁹ Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
¹⁰ Columbus Technologies, Inc., Contractor to the National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, MD, USA.
¹¹ Global Neurology Program, Division of Neuro-Immunology, Center for Virology and Vaccine Research, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
¹² Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.
¹³ Center for Infectious Disease Imaging, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
¹⁴ Sabin Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
¹⁵ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
¹⁶ Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
¹⁷ Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA. zfabry@wisc.edu.

Abstract

Tuberculous meningitis is a serious, life-threatening disease affecting vulnerable populations, including HIV-infected individuals and young children. The US National Institutes of Health convened a workshop to identify knowledge gaps in the molecular and immunopathogenic mechanisms of tuberculous meningitis and to develop a roadmap for basic and translational research that could guide clinical studies.

Tuberculous meningitis: a roadmap for advancing basic and translational research

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