Novel FGFR2-INA fusion identified in two low-grade mixed neuronal-glial tumors drives oncogenesis via MAPK and PI3K/mTOR pathway activation

Acta Neuropathol. 2018 Jul;136(1):167-169. doi: 10.1007/s00401-018-1864-5. Epub 2018 May 16.

Payal Jain¹, Lea F Surrey^{2

3}, Joshua Straka¹, Minjie Luo^{2

3}, Fumin Lin², Brian Harding^{2

3}, Adam C Resnick¹, Phillip B Storm⁴, Anna Maria Buccoliero⁵, Mariarita Santi^{2

3}, Marilyn M Li^{1

2

3

6}, Angela J Waanders^{7

8

9}

¹ Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
² Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
³ Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Department of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
⁵ Meyer Children's Hospital, Florence, Italy.
⁶ Department of Pediatrics, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 19104, USA.
⁷ Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA, 19104, USA. WAANDERSA@email.chop.edu.
⁸ Department of Pediatrics, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 19104, USA. WAANDERSA@email.chop.edu.
⁹ Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. WAANDERSA@email.chop.edu.

No abstract available

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