Transition-Metal-Free Reductive Deoxygenative Olefination with CO2

Org Lett. 2018 Jun 1;20(11):3282-3285. doi: 10.1021/acs.orglett.8b01155. Epub 2018 May 15.

Abstract

A new transition-metal-free reductive deoxygenative olefination of phosphorus ylides with CO2, an abundant and sustainable C1 chemical feedstock, is described. This catalytic CO2 fixation afforded β-unsubstituted acrylates and vinyl ketones in good yields with broad scope and good functional group tolerance under mild reaction conditions. Cost-effective and easily handled polymethylhydrosiloxane was used as a reductant. Bis(silyl)acetal was proved to be the key intermediate in this reductive functionalization of CO2.

Publication types

  • Research Support, Non-U.S. Gov't