Elastase Digestion of Fibronectin Releases an Epiviosamine Peptide with Fibroblast Growth and Survival Activity

J Invest Dermatol. 2018 Nov;138(11):2480-2483. doi: 10.1016/j.jid.2018.04.023. Epub 2018 May 9.

Authors

Kevin Lin¹, Fubao Lin², Richard A Clark³

Affiliations

¹ Biology Department, Vassar College, Poughkeepsie, New York, USA.
² Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA; Department of Dermatology, Stony Brook University, Stony Brook, NY, USA.
³ Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA; Department of Dermatology, Stony Brook University, Stony Brook, NY, USA. Electronic address: richard.clark@stonybrook.edu.

PMID: 29753030
DOI: 10.1016/j.jid.2018.04.023

No abstract available

Publication types

Letter
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adult
Aged
Aged, 80 and over
Becaplermin / metabolism*
Burns / drug therapy
Cell Proliferation
Cell Survival
Cells, Cultured
Female
Fibroblasts / physiology*
Fibronectins / metabolism*
Humans
Hydrogen Peroxide / metabolism
Male
Middle Aged
Oxidative Stress
Pancreatic Elastase / metabolism*
Peptide Fragments / metabolism*
Proteolysis
Skin / pathology*

Substances

Fibronectins
Peptide Fragments
Becaplermin
Hydrogen Peroxide
Pancreatic Elastase

Grants and funding

S10 OD020155/OD/NIH HHS/United States