MIBG scintigraphy of the major salivary glands in multiple system atrophy

Luisa Soboll; Daniela Leppert; Ulrich Dillmann; Andrea Schaefer-Schuler; Klaus Fassbender; Samer Ezziddin; Jörg Spiegel

doi:10.1016/j.parkreldis.2018.04.034

MIBG scintigraphy of the major salivary glands in multiple system atrophy

Parkinsonism Relat Disord. 2018 Aug:53:112-114. doi: 10.1016/j.parkreldis.2018.04.034. Epub 2018 May 4.

Authors

Luisa Soboll¹, Daniela Leppert², Ulrich Dillmann¹, Andrea Schaefer-Schuler², Klaus Fassbender¹, Samer Ezziddin², Jörg Spiegel³

Affiliations

¹ Department of Neurology, Saarland University, D-66421 Homburg/Saar, Germany.
² Department of Nuclear Medicine, Saarland University, D-66421 Homburg/Saar, Germany.
³ Department of Neurology, Saarland University, D-66421 Homburg/Saar, Germany. Electronic address: joerg.spiegel@uks.eu.

PMID: 29752191
DOI: 10.1016/j.parkreldis.2018.04.034

Abstract

We applied MIBG scintigraphy to measure the sympathetic innervation of the major salivary glands in 28 patients with multiple system atrophy (MSA) and 15 controls. MIBG uptake did not differ significantly between MSA patients and controls. This normal MIBG uptake correlates with predominantly intact postganglionic sympathetic innervation in MSA.

Keywords: Lewy body degeneration; MIBG scintigraphy; Major salivary glands; Multiple system atrophy.

Publication types

Letter

MeSH terms

3-Iodobenzylguanidine*
Humans
Multiple System Atrophy / diagnostic imaging*
Parkinson Disease / diagnostic imaging*
Radionuclide Imaging / methods*
Radionuclide Imaging / standards
Salivary Glands / diagnostic imaging*
Salivary Glands / innervation*
Sympathetic Nervous System / diagnostic imaging*

Substances

3-Iodobenzylguanidine