A new menthane-type monoterpenoid from fermented Illigera aromatica with Clonostachys rogersoniana 828H2

Jian-Wei Dong; Le Cai; Xue-Jiao Li; Ya-Xian Shi; Jia-Peng Wang; Rui-Feng Mei; Zhong-Tao Ding

doi:10.1080/10286020.2018.1467403

A new menthane-type monoterpenoid from fermented Illigera aromatica with Clonostachys rogersoniana 828H2

J Asian Nat Prod Res. 2019 Jul;21(7):673-678. doi: 10.1080/10286020.2018.1467403. Epub 2018 May 11.

Authors

Jian-Wei Dong^{1

2}, Le Cai², Xue-Jiao Li^{1

2}, Ya-Xian Shi², Jia-Peng Wang², Rui-Feng Mei², Zhong-Tao Ding²

Affiliations

¹ a College of Chemistry and Environmental Science , Qujing Normal University , Qujing 655011 , China.
² b Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province , School of Chemical Science and Technology, Yunnan University , Kunming 650091 , China.

PMID: 29749266
DOI: 10.1080/10286020.2018.1467403

Abstract

A new menthane-type monoterpenoid, illigerate E (1), as well as two known ones, (1R^*,3R^*,4S^*,6R^*)-6,8-dihydroxymenthol (2) and cis-4-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one (3), were isolated from fermented Illigera aromatica with Clonostachys rogersoniana 828H2. Their structures were identified by HRESIMS and 1D/2D NMR spectra. Their inhibitory effects of NO production in RAW 264.7 macrophages were estimated.

Keywords: Hernandiaceae; fermentation; monoterpenoid.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Fermentation
Hernandiaceae / chemistry*
Hypocreales / chemistry*
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Monoterpenes / chemistry*
Monoterpenes / pharmacology*
Nitric Oxide / antagonists & inhibitors
Nitric Oxide / biosynthesis
RAW 264.7 Cells
Spectrometry, Mass, Electrospray Ionization

Substances

Anti-Inflammatory Agents, Non-Steroidal
Monoterpenes
Nitric Oxide