Abstract
Based on the nonlinear fluorescence enhancement, our H2O2 induced supramolecular self-assembly reveals a H2O2 threshold among multiple cancer and normal cells. Oxidative elimination restores an intramolecular hydrogen bond which can planarize the molecule to generate a fluorophore. The planarization enhances the intermolecular π-π stacking to promote self-assembly.
MeSH terms
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Cell Line, Tumor
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Fluorescence
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacology*
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Humans
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Hydrogen Bonding
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Hydrogen Peroxide / chemistry
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Nanofibers / chemistry
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Neoplasms / diagnostic imaging*
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Oxidation-Reduction
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Peptides / chemical synthesis
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Peptides / chemistry
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Peptides / pharmacology*
Substances
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Fluorescent Dyes
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Peptides
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Hydrogen Peroxide