Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets

Blood Adv. 2018 May 8;2(9):1040-1045. doi: 10.1182/bloodadvances.2017014001.

Simon Stritt^{1

2}, Inga Birkholz^{1

2}, Sarah Beck^{1

2}, Simona Sorrentino³, K Tanuj Sapra³, Julien Viaud⁴, Johannes Heck¹, Frédérique Gaits-Iacovoni⁴, Harald Schulze¹, Xiaoping Du⁵, John H Hartwig⁶, Attila Braun^{1

2}, Markus Bender^{1

2}, Ohad Medalia^{3

7}, Bernhard Nieswandt^{1

2}

¹ Institute of Experimental Biomedicine I, University Hospital, and.
² Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.
³ Department of Biochemistry, University of Zurich, Zurich, Switzerland.
⁴ INSERM, U1048 and Université Toulouse 3, Toulouse, France.
⁵ Department of Pharmacology, University of Illinois, Chicago, IL.
⁶ Brigham and Women's Hospital, Harvard Medical School, Boston, MA; and.
⁷ Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University, Beer-Sheva, Israel.

Abstract

Profilin 1–mediated cytoskeletal dynamics regulate platelet β1- and β3-integrin function and turnover.
Profilin 1 deficiency in platelets impairs hemostasis and results in a marked protection from arterial thrombosis.