Immunogenicity of a heat-treated recombinant DNA hepatitis B vaccine

Vaccine. 1988 Oct;6(5):399-400. doi: 10.1016/0264-410x(88)90137-5.

Abstract

The effect of heating on the reactogenicity and the immunogenicity of a recombinant DNA hepatitis B vaccine was examined. Treatment of this vaccine for one week at 37 degrees C did not significantly alter these properties when compared to vaccine stored at 4 degrees C. These results have important implications in countries where facilities for the transport and handling of vaccines are often inadequate.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antigens, Viral / immunology*
  • Cold Temperature
  • Hepatitis B Antibodies / biosynthesis
  • Hepatitis B Vaccines
  • Hot Temperature*
  • Humans
  • Preservation, Biological
  • Vaccines / immunology*
  • Vaccines, Synthetic / immunology*
  • Viral Hepatitis Vaccines / immunology*

Substances

  • Antigens, Viral
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines
  • Vaccines
  • Vaccines, Synthetic
  • Viral Hepatitis Vaccines