Chemistry Takes Center Stage for Identifying Cancer Targetability

Christopher G Parker; Benjamin F Cravatt

doi:10.1016/j.cell.2018.04.020

Chemistry Takes Center Stage for Identifying Cancer Targetability

Cell. 2018 May 3;173(4):815-817. doi: 10.1016/j.cell.2018.04.020.

Authors

Christopher G Parker¹, Benjamin F Cravatt²

Affiliations

¹ Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: cparker@scripps.edu.
² Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.

PMID: 29727668
DOI: 10.1016/j.cell.2018.04.020

Abstract

Matching genetically defined cancer states to drugs that specifically target these states is a principal goal of personalized oncology medicine. In this issue, McMillan et al. show how large-scale chemical screening coupled to deep molecular profiling can identify mechanistically diverse druggable vulnerabilities for genetic subtypes of lung cancers.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Gene Expression Profiling*
Humans
Lung Neoplasms*
Molecular Targeted Therapy
Precision Medicine