Longstanding disease-free survival in idiopathic REM sleep behavior disorder: Is neurodegeneration inevitable?

Parkinsonism Relat Disord. 2018 Sep:54:99-102. doi: 10.1016/j.parkreldis.2018.04.010. Epub 2018 Apr 4.

Abstract

Introduction: Studies estimate that >80% of patients with idiopathic REM sleep behavior disorder (iRBD) eventually develop parkinsonism or dementia. However, a small group remains disease-free for long periods, raising the question of whether they truly have prodromal disease.

Methods: We selected subjects with iRBD who were diagnosed at least 10 years previously, and were still disease free (longstanding iRBD) (n = 11). We compared them to 'early converters' (n = 27) defined as those who phenoconverted to parkinsonism or dementia within 4 years after diagnosis, and to age- and sex-matched healthy controls (n = 68). We compared the frequency and progression of numerous markers of prodromal synucleinopathy between groups, and assessed likelihood of meeting prodromal Parkinson's disease criteria.

Results: After at least 10 years follow-up, almost all longstanding iRBD subjects showed multiple features of neurodegeneration, and 9/11 met criteria for prodromal PD. Evolution of markers was slower than early-converters, with an annual increase in prodromal PD probability of 3.9 ± 3.2% in longstanding iRBD compared to 12.4 ± 7.8% for early-convertors (p-value = 0.002). However, subjects with longstanding iRBD at their last visit had similar prodromal measures as the baseline evaluation of the early-convertors, with similarly-abnormal UPDRS scores, quantitative motor tests, cognition and autonomic symptoms and signs.

Conclusion: Although phenoconversion rates can differ dramatically between patients, almost all individuals with iRBD in our cohort appear to have underlying neurodegeneration.

Keywords: Longstanding iRBD; Neurodegeneration; α-Synucleinopathies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cognitive Dysfunction / diagnosis*
  • Cognitive Dysfunction / epidemiology
  • Cognitive Dysfunction / physiopathology
  • Dementia / diagnosis*
  • Dementia / epidemiology
  • Dementia / physiopathology
  • Disease Progression*
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neurodegenerative Diseases / diagnosis*
  • Neurodegenerative Diseases / epidemiology
  • Neurodegenerative Diseases / physiopathology
  • Parkinsonian Disorders / diagnosis*
  • Parkinsonian Disorders / epidemiology
  • Parkinsonian Disorders / physiopathology
  • Prodromal Symptoms*
  • REM Sleep Behavior Disorder / diagnosis*
  • REM Sleep Behavior Disorder / epidemiology
  • REM Sleep Behavior Disorder / physiopathology
  • Risk Assessment