Monoterpene indole alkaloids from Rhazya stricta

Abrar Ahmed; Wei Li; Fang-Fang Chen; Jun-Sheng Zhang; Ya-Qi Tang; Lin Chen; Gui-Hua Tang; Sheng Yin

doi:10.1016/j.fitote.2018.04.018

Monoterpene indole alkaloids from Rhazya stricta

Fitoterapia. 2018 Jul:128:1-6. doi: 10.1016/j.fitote.2018.04.018. Epub 2018 Apr 30.

Authors

Abrar Ahmed¹, Wei Li¹, Fang-Fang Chen¹, Jun-Sheng Zhang¹, Ya-Qi Tang¹, Lin Chen¹, Gui-Hua Tang², Sheng Yin¹

Affiliations

¹ School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
² School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, PR China. Electronic address: tanggh5@mail.sysu.edu.cn.

PMID: 29723561
DOI: 10.1016/j.fitote.2018.04.018

Abstract

Twenty-seven monoterpene indole alkaloids (MIAs) including three new ones were isolated from the plant of Rhazya stricta. Their structures were elucidated by analyses of HRMS and NMR data. Secopleiocarpamine A (1) represents a novel 2,3-seco pleiocarpamine type MIA possessing a cyano group. A possible biosynthetic pathway for 1 was postulated. All compounds were evaluated for their inhibitory activities against six Candida strains, and the results showed that 2, 5, 12, 21, 23, and 27 exhibited moderate inhibitory activities with MIC values ranging from 3.125 to 50 μg/mL.

Keywords: Antifungal activity; Apocynaceae; Monoterpene indole alkaloids; Rhazya stricta.

MeSH terms

Apocynaceae / chemistry*
Candida / drug effects
Indole Alkaloids / isolation & purification*
Microbial Sensitivity Tests
Molecular Structure
Monoterpenes / isolation & purification*

Substances

Indole Alkaloids
Monoterpenes