Time to Decision and Treatment With tPA (Tissue-Type Plasminogen Activator) Using Telemedicine Versus an Onboard Neurologist on a Mobile Stroke Unit

Stroke. 2018 Jun;49(6):1528-1530. doi: 10.1161/STROKEAHA.117.020585. Epub 2018 May 2.

Abstract

Background and purpose: Mobile stroke units (MSUs) can speed treatment with intravenous tPA (tissue-type plasminogen activator). We previously showed substantial agreement between a telemedicine-based vascular neurologist (TM-VN) and an onboard vascular neurologist (OB-VN) for the evaluation of patients with stroke for tPA eligibility on an MSU. However, the time efficiency of the telemedicine-based evaluation remained uncertain. In this study, we examined the speed of decision and treatment from MSU arrival for the TM-VN compared with an OB-VN.

Methods: In 50 consecutive situations, the TM-VN served as the primary decision maker. Times from MSU arrival to tPA decision and tPA bolus were compared with the same metrics for when the OB-VN served as the primary decision maker.

Results: Time to tPA decision for the TM-VN was 21 minutes (interquartile range, 16.25-26) versus 18 minutes (interquartile range, 14-22) for the OB-VN (P=0.01). Initiation of tPA bolus was 24 minutes (interquartile range, 19.75-30) for the TM-VN versus 24 minutes (interquartile range, 19-27.75) for the OB-VN (P=0.5).

Conclusions: Assessment by a TM-VN is comparable with an OB-VN in making decisions about tPA administration on an MSU and does not lead to treatment delays.

Clinical trial registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02190500.

Keywords: ambulances; humans; stroke; telemedicine; uncertainty.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Ischemia / drug therapy
  • Female
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Male
  • Mobile Health Units*
  • Stroke / therapy*
  • Telemedicine* / methods
  • Thrombolytic Therapy / methods
  • Time Factors
  • Tissue Plasminogen Activator / therapeutic use*
  • Treatment Outcome

Substances

  • Fibrinolytic Agents
  • Tissue Plasminogen Activator

Associated data

  • ClinicalTrials.gov/NCT02190500