Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks

Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2909-2912. doi: 10.1002/1521-3773(20010803)40:15<2909::AID-ANIE2909>3.0.CO;2-O.

Abstract

DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin. The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

Keywords: DNA structures; nanostructures; oligonucleotides; proteins; small-angle X-ray scattering.