The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

David S Knopman; Samantha Budd Haeberlein; Maria C Carrillo; James A Hendrix; Geoff Kerchner; Richard Margolin; Paul Maruff; David S Miller; Gary Tong; Maria B Tome; Melissa E Murray; Peter T Nelson; Mary Sano; Niklas Mattsson; David L Sultzer; Thomas J Montine; Clifford R Jack Jr; Hartmuth Kolb; Ronald C Petersen; Prashanthi Vemuri; Megan Zoschg Canniere; Julie A Schneider; Susan M Resnick; Gary Romano; Argonde Corien van Harten; David A Wolk; Lisa J Bain; Eric Siemers

doi:10.1016/j.jalz.2018.03.002

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Alzheimers Dement. 2018 Apr;14(4):563-575. doi: 10.1016/j.jalz.2018.03.002.

Authors

David S Knopman¹, Samantha Budd Haeberlein², Maria C Carrillo³, James A Hendrix⁴, Geoff Kerchner⁵, Richard Margolin⁶, Paul Maruff⁷, David S Miller⁸, Gary Tong⁹, Maria B Tome¹⁰, Melissa E Murray¹¹, Peter T Nelson¹², Mary Sano¹³, Niklas Mattsson¹⁴, David L Sultzer¹⁵, Thomas J Montine¹⁶, Clifford R Jack Jr¹, Hartmuth Kolb¹⁷, Ronald C Petersen¹, Prashanthi Vemuri¹, Megan Zoschg Canniere¹⁸, Julie A Schneider¹⁹, Susan M Resnick²⁰, Gary Romano²¹, Argonde Corien van Harten²², David A Wolk²³, Lisa J Bain²⁴, Eric Siemers²⁵

Affiliations

¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
² Biogen, Cambridge, MA, USA.
³ Alzheimer's Association, Chicago, IL, USA.
⁴ Alzheimer's Association, Chicago, IL, USA. Electronic address: jhendrix@alz.org.
⁵ Genentech, Inc., South San Francisco, CA, USA.
⁶ Pfizer, New York, NY, USA.
⁷ Cogstate Ltd, Melbourne, Victoria, Australia.
⁸ Bracket, Wayne, PA, USA.
⁹ Lundbeck, Deerfield, IL, USA.
¹⁰ European Medicines Agency (EMA), London, UK.
¹¹ Mayo Clinic, Jacksonville, FL, USA.
¹² University of Kentucky, Lexington, KY, USA.
¹³ Mount Sinai School of Medicine, New York, NY, USA.
¹⁴ Clinical Memory Research Unit, Lund University, Lund, Sweden.
¹⁵ David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹⁶ Department of Pathology, Stanford University, Stanford, CA, USA.
¹⁷ Janssen Research and Development, San Diego, CA, USA.
¹⁸ Hoffmann-La Roche, Inc., Basel, Switzerland.
¹⁹ Rush University Medical Center, Chicago, IL, USA.
²⁰ National Institute on Aging, Baltimore, MD, USA.
²¹ Janssen R&D, Titusville, NJ, USA.
²² VU University Medical Center, Amsterdam, the Netherlands.
²³ Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
²⁴ Independent Science Writer, Elverson, PA, USA.
²⁵ Eli Lilly and Company, Indianapolis, IN, USA.

Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the "A, T, N System" (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

Keywords: Alzheimer's disease; Amyloid; Biomarkers; Clinical trials; Neurodegeneration; Tau.

Publication types

Review

MeSH terms

Alzheimer Disease / diagnosis*
Alzheimer Disease / physiopathology
Alzheimer Disease / therapy*
Biomarkers / metabolism
Clinical Trials as Topic*
Drug Development
Humans
National Institute on Aging (U.S.)
United States

Substances

Biomarkers

Abstract

Publication types

MeSH terms

Substances

Grants and funding