Antigen processing and presentation in HIV infection

Julie Boucau; Sylvie Le Gall

doi:10.1016/j.molimm.2018.03.027

Antigen processing and presentation in HIV infection

Mol Immunol. 2019 Sep:113:67-74. doi: 10.1016/j.molimm.2018.03.027. Epub 2018 Apr 7.

Authors

Julie Boucau¹, Sylvie Le Gall²

Affiliations

¹ Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States.
² Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, United States. Electronic address: sylvie_legall@hms.harvard.edu.

Abstract

The presentation of virus-derived peptides by MHC molecules constitutes the earliest signals for immune recognition by T cells. In HIV infection, immune responses elicited during infection do not enable to clear infection and correlates of immune protection are not well defined. Here we review features of antigen processing and presentation specific to HIV, analyze how HIV has adapted to the antigen processing machinery and discuss how advances in biochemical and computational protein degradation analyses and in immunopeptidome definition may help identify targets for efficient immune clearance and vaccine immunogen design.

Keywords: HIV; Immune escape; Immunopeptidome; Protein degradation; T cells; Vaccine immunogen design.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

AIDS Vaccines / immunology
Animals
Antigen Presentation / immunology*
HIV Infections / immunology*
HIV-1 / immunology*
Histocompatibility Antigens / immunology
Humans

Substances

AIDS Vaccines
Histocompatibility Antigens

Abstract

Publication types

MeSH terms

Substances

Grants and funding