Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients

Edward Cha; Lawrence Fong

doi:10.4161/21624011.2014.956016

Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients

Oncoimmunology. 2018 Mar 13;7(4):e956016. doi: 10.4161/21624011.2014.956016. eCollection 2018.

Authors

Edward Cha¹, Lawrence Fong¹

Affiliation

¹ University of California, San Francisco, San Francisco, CA.

Abstract

CTLA-4 inhibition produces durable T cell-driven antitumor responses, but understanding which patients achieve a long-term benefit remains unclear. Deep sequencing of rearranged T cell receptor β (TCRβ) genes can monitor the effects of CTLA-4 inhibition and potentially identify patients with long-term survival.

Keywords: CTLA-4; T cell repertoire; immune checkpoint; ipilimumab; next generation sequencing; tremelimumab.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Grants and funding

R01 CA136753/CA/NCI NIH HHS/United States