Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients

Antonio Checa; Anna Malmqvist; Lena Flyckt; Lilly Schwieler; Martin Samuelsson; Elisabeth Skogh; Simon Cervenka; Marja-Liisa Dahl; Fredrik Piehl; Karolinska Schizophrenia Project (KaSP) Consortium; Sophie Erhardt; Craig E Wheelock

doi:10.1016/j.schres.2018.03.029

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients

Schizophr Res. 2018 Sep:199:438-441. doi: 10.1016/j.schres.2018.03.029. Epub 2018 Apr 4.

Collaborators

Karolinska Schizophrenia Project (KaSP) Consortium:
L Farde⁷, L Flyckt⁷, G Engberg², S Erhardt², H Fatouros-Bergman⁷, S Cervenka⁷, L Schwieler², F Piehl⁸, I Agartz⁹, K Collste⁷, P Victorsson⁷, A Malmqvist², M Hedberg², F Orhan²

Affiliations

¹ Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
² Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
³ Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, Sweden.
⁴ Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden; Department of Psychiatry, Local Health Care Services in Central Östergötland, Region Östergötland, Linköping, Sweden.
⁵ Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
⁶ Department of Clinical Neurosciences, Section of Neurology, Karolinska Institutet, Stockholm, Sweden.
⁷ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm County Council, Stockholm, Sweden.
⁸ Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
⁹ Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm County Council, Stockholm, Sweden; NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway; Department of Psychiatry Research, Diakonhjemmet Hospital, Oslo, Norway.
¹⁰ Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address: craig.wheelock@ki.se.

PMID: 29627172
DOI: 10.1016/j.schres.2018.03.029

No abstract available

Keywords: Biomarkers; Cerebrospinal fluid; Demyelination; Schizophrenia; Sphingolipids.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Ceramides / cerebrospinal fluid
Female
Humans
Male
Psychotic Disorders / cerebrospinal fluid*
Psychotic Disorders / physiopathology*
Severity of Illness Index
Sphingolipids / cerebrospinal fluid*
Sphingomyelins / cerebrospinal fluid
Young Adult

Substances

Ceramides
Sphingolipids
Sphingomyelins