Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus

Bioorg Med Chem Lett. 2018 May 15;28(9):1516-1519. doi: 10.1016/j.bmcl.2018.03.080. Epub 2018 Mar 30.

Abstract

A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC50 values of 16.5, 12.5, 13.1, and 18.5 μM, respectively, which were better than the positive control Ribavirin (IC50 22.6 μM). .

Keywords: Influenza A virus; Ligustrum lucidum; Oleaceae; Secoiridoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Dose-Response Relationship, Drug
  • Fruit / chemistry*
  • Influenza A virus / drug effects*
  • Iridoid Glucosides / chemistry
  • Iridoid Glucosides / isolation & purification
  • Iridoid Glucosides / pharmacology*
  • Ligustrum / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Structure-Activity Relationship

Substances

  • Antiviral Agents
  • Iridoid Glucosides