Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage

Hijai R Shin; Roberto Zoncu

doi:10.1016/j.molcel.2018.03.017

Finding Sugar in the Pantry: How Galectins Detect and Signal Lysosomal Damage

Mol Cell. 2018 Apr 5;70(1):5-7. doi: 10.1016/j.molcel.2018.03.017.

Authors

Hijai R Shin¹, Roberto Zoncu²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; The Paul F. Glenn Center for Aging Research at the University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rzoncu@berkeley.edu.

PMID: 29625038
DOI: 10.1016/j.molcel.2018.03.017

Abstract

In this issue of Molecular Cell, Jia et al. (2018) identify a lysosomal damage-response pathway centered on galectin 8 and 9 that feeds back on mTORC1 signaling. In response to lysosome-damaging agents, galectins inhibits mTORC1, triggering a stress response that may help restore cellular homeostasis.

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MeSH terms

Galectins*
Lysosomes
Signal Transduction
Sugars*
TOR Serine-Threonine Kinases

Substances

Galectins
Sugars
TOR Serine-Threonine Kinases