Pulling the genome in opposite directions to dissect gene networks

Genome Biol. 2018 Mar 26;19(1):42. doi: 10.1186/s13059-018-1425-1.

Authors

Charles A Gersbach^{1

2}, Rodolphe Barrangou³

Affiliations

¹ Department of Biomedical Engineering, Center for Genomic and Computational Biology, Duke University, Durham, NC, USA. charles.gersbach@duke.edu.
² Department of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA. charles.gersbach@duke.edu.
³ Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, 27695, USA. rbarran@ncsu.edu.

Abstract

Orthogonal CRISPR-Cas systems have been integrated into combinatorial screens to decipher complex genetic relationships in two recent studies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

CRISPR-Associated Protein 9*
CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats*
Gene Regulatory Networks
Genome

Substances

CRISPR-Associated Protein 9

Grants and funding