Diverse mechanisms of IRF5 action in inflammatory responses

Int J Biochem Cell Biol. 2018 Jun:99:38-42. doi: 10.1016/j.biocel.2018.03.012. Epub 2018 Mar 22.

Abstract

Interferon regulatory factor 5 (IRF5) is a key signal-dependent transcription factor in myeloid cells. Its expression is induced by granulocyte-macrophage colony stimulating factor and interferon-gamma. IRF5 protein is further activated in response to stimulation, translocating to the nucleus where it mediates inflammatory responses. IRF5 is capable of both the up-regulation of pro-inflammatory genes and repressing anti-inflammatory mediators, thus polarising macrophages to a pro-inflammatory phenotype. We discuss IRF5 interactions with a wide range of transcriptional regulators that give rise to its diverse effects at the level of chromatin.

Keywords: IRF5; Inflammation; Myeloid cells; Transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation*
  • Humans
  • Inflammation / physiopathology*
  • Interferon Regulatory Factors / genetics
  • Interferon Regulatory Factors / metabolism*

Substances

  • IRF5 protein, human
  • Interferon Regulatory Factors