Tumor-derived exosomes modulate T cell function through transfer of RNA

Imran G House; Emma V Petley; Paul A Beavis

doi:10.1111/febs.14413

Tumor-derived exosomes modulate T cell function through transfer of RNA

FEBS J. 2018 Mar;285(6):1030-1032. doi: 10.1111/febs.14413.

Authors

Imran G House^{1

2}, Emma V Petley^{1

2}, Paul A Beavis^{1

2

3}

Affiliations

¹ Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Australia.
² Sir Peter MacCallum Department of Oncology, The University of Melbourne, Australia.
³ Department of Pathology, University of Melbourne, Australia.

PMID: 29570251
DOI: 10.1111/febs.14413

Abstract

Tumor cells can develop a variety of mechanisms to evade and subvert the immune system for their survival. Bland et al., in this edition of The FEBS Journal, make the novel finding that the tumor line B16F0 can deliver mRNA/miRNA loaded exosomes to cytotoxic T lymphocytes and alter their metabolic function and interferon gamma production.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Exosomes*
Humans
Melanoma
MicroRNAs
T-Lymphocytes, Cytotoxic*
Transcriptome

Substances

MicroRNAs