Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099

Selective inhibition of leukemia-associated SHP2^E69K mutant by the allosteric SHP2 inhibitor SHP099

Leukemia. 2018 May;32(5):1246-1249. doi: 10.1038/s41375-018-0020-5. Epub 2018 Jan 30.

X Sun¹, Y Ren², S Gunawan³, P Teng⁴, Z Chen², H R Lawrence³, J Cai⁴, N J Lawrence³, J Wu^{5

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¹ Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
² Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
³ Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
⁴ Department of Chemistry, University of South Florida, Tampa, FL, USA.
⁵ Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jie-wu@ouhsc.edu.
⁶ Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. jie-wu@ouhsc.edu.
⁷ Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. jie-wu@ouhsc.edu.

No abstract available