T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation

Eur Respir J. 2018 Mar 22;51(3):1800153. doi: 10.1183/13993003.00153-2018. Print 2018 Mar.

Authors

Munyaradzi Musvosvi¹, Darragh Duffy^{2

3}, Elizabeth Filander¹, Hadn Africa¹, Simbarashe Mabwe¹, Lungisa Jaxa¹, Nicole Bilek¹, Alba Llibre^{2

3}, Vincent Rouilly^{2

3}, Mark Hatherill¹, Matthew Albert^{2

3

4}, Thomas J Scriba^{1

5}, Elisa Nemes^{1

5}

Affiliations

¹ South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa.
² Laboratory of Dendritic Cell Immunobiology, Dept of Immunology, Institut Pasteur, Paris, France.
³ INSERM U1223, Paris, France.
⁴ Cancer Immunology, Genentech, Inc., South San Francisco, CA, USA.
⁵ These authors contributed equally.

PMID: 29567725
DOI: 10.1183/13993003.00153-2018

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Biomarkers / metabolism*
HLA-DR Antigens / metabolism*
Healthy Volunteers
Humans
Latent Tuberculosis / blood*
Latent Tuberculosis / diagnosis*
Latent Tuberculosis / immunology
Leukocytes, Mononuclear / metabolism
Mycobacterium tuberculosis
Phenotype
ROC Curve
Reproducibility of Results
South Africa
T-Lymphocytes / metabolism*
Translational Research, Biomedical

Substances

Biomarkers
HLA-DR Antigens