Increased Prevalence of Thyroid Disease in Patients with Antineutrophil Cytoplasmic Antibodies-associated Vasculitis

J Rheumatol. 2018 May;45(5):686-689. doi: 10.3899/jrheum.170661. Epub 2018 Mar 15.

Abstract

Objective: Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) has been linked with thyroid disease as a result of antithyroid medications. We assessed the prevalence of thyroid disease in our patients with AAV.

Methods: Clinical records of 279 patients with AAV diagnosed between 1991 and 2014 were analyzed.

Results: Thyroid disease was identified in 21.5% of patients, but only 2 had previously received propylthiouracil. There was a greater proportion of female patients, patients with antimyeloperoxidase antibodies, and patients with renal disease in the group with thyroid disease.

Conclusion: Our data show a higher prevalence of thyroid disease in patients with AAV than the general population. This was not attributable to antithyroid drugs.

Keywords: ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; AUTOIMMUNE DISEASE; THYROID DISEASE; VASCULITIS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / pathology*
  • Antibodies / blood
  • Antithyroid Agents / adverse effects*
  • Antithyroid Agents / therapeutic use
  • Chi-Square Distribution
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Diseases / complications
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Peroxidase / immunology
  • Prevalence
  • Propylthiouracil / adverse effects*
  • Propylthiouracil / therapeutic use
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Statistics, Nonparametric
  • Thyroid Diseases / complications
  • Thyroid Diseases / epidemiology*

Substances

  • Antibodies
  • Antithyroid Agents
  • Propylthiouracil
  • MPO protein, human
  • Peroxidase