We conducted serial neurological examinations on 50 patients of non-traumatic coma to identify factors predicting recovery. During the course of the study 40 (80 percent) patients died, 1 (2 percent ) survived with sever disability, 3 (6 percent) survived with moderate disability and 6 (12 percent) made good recovery. Status of pupillary and oculocephalic reflex was found to be statistically significant to judge the prognosis. No patient made good recovery when any two brain stem reflexes were absent.