Vitamin D levels are associated with epistaxis severity and bleeding duration in hereditary hemorrhagic telangiectasia

Biomark Med. 2018 Apr;12(4):365-371. doi: 10.2217/bmm-2017-0229. Epub 2018 Mar 14.

Abstract

Aim: To explore the association between vitamin D levels and mild versus severe epistaxis, as well as the overall epistaxis severity score (ESS) in patients with hereditary hemorrhagic telangiectasia.

Patients & methods: A retrospective chart review of 198 patients was performed to explore the relationship between vitamin D levels and the ESS. Vitamin D levels were also compared with those with mild epistaxis to those with severe epistaxis.

Results: A significant difference was found between patient's vitamin D levels and their associated ESS and duration of epistaxis. Patients with mild epistaxis had higher levels of vitamin D than patients with severe epistaxis.

Conclusion: Vitamin D is associated with features of hereditary hemorrhagic telangiectasia including ESS, bleeding time and epistaxis severity.

Keywords: Osler–Weber–Rendu; biomarker; epistaxis; hereditary hemorrhagic telangiectasia; vitamin D.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Epistaxis / complications*
  • Epistaxis / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Telangiectasia, Hereditary Hemorrhagic / complications*
  • Time Factors
  • Vitamin D / metabolism*
  • Young Adult

Substances

  • Vitamin D