The utility of pharmacokinetic studies for the evaluation of exposure-response relationships for standard dose anti-tuberculosis drugs

Tuberculosis (Edinb). 2018 Jan:108:77-82. doi: 10.1016/j.tube.2017.11.004. Epub 2017 Nov 7.

Abstract

Tuberculosis (TB) is a major public health problem. Many countries still fall below the minimum World Health Organization (WHO) TB treatment target success rate. There is conflicting evidence about whether concentrations of anti-tuberculosis drugs given at standard doses have an effect on treatment outcomes. The current data correlating anti-TB drug concentrations and treatment outcome is limited. This article summarized the existing literature and their utility in evaluating the association between each anti-TB drug's concentrations using current target concentrations and treatment outcomes in patients with pulmonary tuberculosis receiving standard WHO-recommended dosing.

Keywords: Anti-tuberculosis drugs; Concentrations; Treatment outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / adverse effects
  • Antitubercular Agents / blood
  • Antitubercular Agents / pharmacokinetics*
  • Dose-Response Relationship, Drug
  • Drug Dosage Calculations
  • Drug Monitoring
  • Humans
  • Models, Biological
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / pathogenicity
  • Treatment Outcome
  • Tuberculosis, Pulmonary / blood
  • Tuberculosis, Pulmonary / diagnosis
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / microbiology

Substances

  • Antitubercular Agents