Microarchitecture and connectivity of the parietal lobe

Abstract

This chapter summarizes current knowledge on the structural segregation of the parietal lobe based on cyto-, myelo-, and receptorarchitectonic studies, as well as the connectivity of this brain region with other cortical and subcortical structures. The anterior part of the human parietal cortex comprises the somatosensory areas 3a, 3b, 1, and 2, whereas the posterior part contains seven multimodal areas in both the superior and inferior parietal lobules. Available cytoarchitectonic maps of the human intraparietal sulcus do not provide a complete picture yet. Myelo- and receptorarchitectonic analyses largely confirm but also further differentiate the cytoarchitectonic maps. With the advent of diffusion imaging and functional connectivity studies, further insight into the structural and functional organization has been achieved. It shows that the posterior parietal cortex is a key node in anatomic networks connecting visual with (pre)frontal cortices, and temporal with parts of frontal cortices. Here, the superior longitudinal fascicle and its components play a major role, together with the arcuate and middle longitudinal fascicles. Major connections with subcortical structures, particularly the basal ganglia and thalamic nuclei, are discussed. Finally, the importance of precise maps of parietal areas for defining seed regions in structural and functional connectivity studies is emphasized.

Keywords: connectivity; cytoarchitecture; human brain; inferior parietal lobule; intraparietal sulcus; macaque brain; myeloarchitecture; parietal cortex; receptorarchitecture; superior parietal lobule.