L-Lysine-α-Oxidase: Acidovorax citrulli Bacterium Inhibitor

Bull Exp Biol Med. 2018 Mar;164(4):459-461. doi: 10.1007/s10517-018-4012-2. Epub 2018 Mar 5.

Abstract

Studies of the effects of Trichoderma harzianum Rifai F-180 culture fluid concentrate containing L-lysine-α-oxidase antitumor enzyme produced by the fungus and the homogenous enzyme, on ultrahazardous bacterium Acidovorax citrulli demonstrated the antibacterial activity of the concentrate. Trichoderma harzianum Rifai F-180 producing L-lysine-α-oxidase was cultured in a technological device at G. K. Skryabin Institute of Biochemistry and. Physiology of Microorganisms, Russian Academy of Sciences. Activity of L-lysine-α-oxidase in the resulted culture fluid concentrate was 0.54 U/ml, activity of the homogenous enzyme was 50 U/mg.

Keywords: Acidovorax citrulli; L-lysine-α-oxidase antitumor enzyme; Trichoderma culture fluid.

MeSH terms

  • Amino Acid Oxidoreductases / isolation & purification
  • Amino Acid Oxidoreductases / pharmacology*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Comamonadaceae / drug effects*
  • Comamonadaceae / growth & development
  • Comamonadaceae / isolation & purification
  • Comamonadaceae / pathogenicity
  • Disk Diffusion Antimicrobial Tests
  • Drug Repositioning
  • Fungal Proteins / isolation & purification
  • Fungal Proteins / pharmacology*
  • Fungicides, Industrial / isolation & purification
  • Fungicides, Industrial / pharmacology*
  • Plants / microbiology
  • Trichoderma / chemistry*
  • Trichoderma / growth & development

Substances

  • Antineoplastic Agents
  • Fungal Proteins
  • Fungicides, Industrial
  • Amino Acid Oxidoreductases
  • L-lysine oxidase