Medical Management of Otosclerosis

Otolaryngol Clin North Am. 2018 Apr;51(2):441-452. doi: 10.1016/j.otc.2017.11.006.

Abstract

Otosclerosis/otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to progressive hearing loss. Diagnosis is usually clinical, based on the findings of anamnesis, physical examination, and audiometric evaluation. However, high-resolution computed tomography scan and MRI have played an important role in the diagnosis and therapeutic approach of otosclerosis and in assisting in the differential diagnosis. The therapeutic approach is aimed at preventing, or at least minimizing, disease progression while attempting to restore hearing. The use of sodium fluoride and bisphosphonates can be an important adjunct, perhaps even primary treatment, in managing active lesions.

Keywords: Computed tomography; Hearing loss; MRI; Otosclerosis; Otospongiosis; Sodium alendronate; Sodium fluoride.

Publication types

  • Review

MeSH terms

  • Diphosphonates / therapeutic use*
  • Hearing Loss / etiology
  • Hearing Loss / prevention & control*
  • Hearing Tests
  • Humans
  • Magnetic Resonance Imaging
  • Otosclerosis / diagnostic imaging*
  • Otosclerosis / drug therapy*
  • Randomized Controlled Trials as Topic
  • Sodium Fluoride / therapeutic use*
  • Tomography, X-Ray Computed

Substances

  • Diphosphonates
  • Sodium Fluoride