Enhanced butyric acid production in Clostridium tyrobutyricum by overexpression of rate-limiting enzymes in the Embden-Meyerhof-Parnas pathway

J Biotechnol. 2018 Apr 20:272-273:14-21. doi: 10.1016/j.jbiotec.2018.02.012. Epub 2018 Mar 6.

Authors

Yukai Suo¹, Hongxin Fu¹, Mengmeng Ren¹, Zhengping Liao¹, Yi Ma¹, Jufang Wang²

Affiliations

¹ School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China.
² School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, China; State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, China. Electronic address: jufwang@scut.edu.cn.

PMID: 29501473
DOI: 10.1016/j.jbiotec.2018.02.012

No abstract available

Keywords: 6-Phosphofructokinase; Butyric acid; Clostridium tyrobutyricum; Metabolic engineering; Pyruvate kinase.

MeSH terms

Adenosine Triphosphate / metabolism
Butyric Acid / metabolism*
Clostridium tyrobutyricum / genetics*
Clostridium tyrobutyricum / growth & development
Clostridium tyrobutyricum / metabolism*
Fermentation
Gene Expression Regulation, Enzymologic
Glucose / metabolism
Glycolysis
NAD / metabolism
Phosphofructokinase-1 / genetics*
Pyruvate Kinase / genetics*

Substances

NAD
Butyric Acid
Adenosine Triphosphate
Phosphofructokinase-1
Pyruvate Kinase
Glucose