Transition-Metal-Free C-P Bond Formation via Decarboxylative Phosphorylation of Cinnamic Acids with P(O)H Compounds

J Org Chem. 2018 Apr 6;83(7):4190-4196. doi: 10.1021/acs.joc.8b00187. Epub 2018 Mar 12.

Abstract

A novel, transition-metal-free phosphorylation of cinnamic acids with P(O)H compounds has been developed via radical-promoted decarboxylation under mild conditions. This method provides simple, efficient, and versatile access to valuable ( E)-alkenylphosphine oxides in satisfactory yields with a wide variety of substrates.

Publication types

  • Research Support, Non-U.S. Gov't