Autonomic symptoms following Zika virus infection

Clin Auton Res. 2018 Apr;28(2):211-214. doi: 10.1007/s10286-018-0515-1. Epub 2018 Mar 1.

Abstract

Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection.

Methods: Case-control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31).

Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001).

Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.

Keywords: Autonomic symptoms; COMPASS 31; Dysautonomia; Flavivirus; Zika virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autonomic Nervous System Diseases / diagnosis
  • Autonomic Nervous System Diseases / etiology*
  • Autonomic Nervous System Diseases / physiopathology*
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Zika Virus Infection / complications*
  • Zika Virus Infection / diagnosis
  • Zika Virus Infection / physiopathology*