Improvement and unification of information and analytical technologies is the one of the priorities, the solution of which will provide the gain in the efficacy and appropriateness of management decisions, developed preventive and wellness measures. In the article there is explained the use of generalized indices of the real risk as criteria for the comprehensive assessment of the health state of the population at the regional and the municipal levels. The proposed criteria make it possible to increase the objectivity of the assessment of the health state in the sociohygienic monitoring system and in the implementation of the special studies of epidemiological type. There are presented results of a comprehensive assessment of the health state of the population in the cities of Rostov region for the ten-year period and according to socio-hygienic monitoring in 2014 year. In terms of twenty of markers characteristics ofpopulation health there were used indices of the total mortality and morbidity rate. There was executed the complex assessment of the cancer prevalence rate in the urban population on nine priority localizations of the malignant tumors, including stomach, colon, rectum, lungs, skin, mammary gland, corpus uteri, ovary and thyroid gland. There were identified territories of high and elevated real risk to health state of the population. There is presented the result of the application of mathematical modeling used for the assessment and prediction of the impact of environmental factors on the complex assessment of the health staty of the population. Results of research were used for the shaping of information and analytical materials in the Rostov region.