Sort Your Self Out!

Cell. 2018 Feb 8;172(4):640-642. doi: 10.1016/j.cell.2018.01.023.

Abstract

Discrimination between viral and self-derived nucleic acid species is crucial in maintaining effective antiviral immunity whilst avoiding autoinflammation. Ahmad et al. and Chung et al. delineate the consequences of MDA5 gain of function and loss of ADAR1 activity, highlighting the blurring of the concept of self and non-self when considering endogenous retroelements.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenosine Deaminase / genetics
  • DEAD-box RNA Helicases / genetics
  • Humans
  • Inflammation
  • RNA Editing*
  • RNA*
  • RNA-Binding Proteins
  • Self Tolerance

Substances

  • RNA-Binding Proteins
  • RNA
  • ADAR protein, human
  • Adenosine Deaminase
  • DEAD-box RNA Helicases