Meddling with METTLs in Normal and Leukemia Stem Cells

Gaëlle H Martin; Christopher Y Park

doi:10.1016/j.stem.2018.01.013

Meddling with METTLs in Normal and Leukemia Stem Cells

Cell Stem Cell. 2018 Feb 1;22(2):139-141. doi: 10.1016/j.stem.2018.01.013.

Authors

Gaëlle H Martin¹, Christopher Y Park²

Affiliations

¹ Department of Pathology, New York University School of Medicine, New York, NY, USA.
² Department of Pathology, New York University School of Medicine, New York, NY, USA. Electronic address: christopher.park@nyumc.org.

PMID: 29395048
DOI: 10.1016/j.stem.2018.01.013

Abstract

Three recent studies independently identified the m⁶A RNA modifying enzymes METTL3 and METTL14 as critical regulators of differentiation in both normal hematopoiesis and AML pathogenesis. These studies expand the described roles of the epitranscriptome in maintaining the undifferentiated state in somatic stem cells and human cancer.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adenosine
Cell Differentiation
Hematopoiesis
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute*
Methyltransferases*
RNA, Messenger

Substances

RNA, Messenger
METTL14 protein, human
Methyltransferases
Adenosine