A Fatal Case of Candida auris and Candida tropicalis Candidemia in Neutropenic Patient

Mycopathologia. 2018 Jun;183(3):559-564. doi: 10.1007/s11046-018-0244-y. Epub 2018 Jan 30.

Abstract

We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested. The use of chromogenic agar as isolation media is vital in detecting mixed candidemia.

Keywords: Candida auris; Mixed candidemia; Multidrug resistant.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / pharmacology
  • Candida / classification*
  • Candida / drug effects
  • Candida / genetics
  • Candida / isolation & purification*
  • Candidemia / diagnosis*
  • Candidemia / microbiology
  • Candidemia / pathology*
  • Coinfection / diagnosis*
  • Coinfection / microbiology
  • Coinfection / pathology*
  • Culture Media / chemistry
  • DNA, Fungal / chemistry
  • DNA, Fungal / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • DNA, Ribosomal Spacer / chemistry
  • DNA, Ribosomal Spacer / genetics
  • Disk Diffusion Antimicrobial Tests
  • Drug Resistance, Multiple, Fungal
  • Fatal Outcome
  • Humans
  • Male
  • Middle Aged
  • Neutropenia / complications*
  • RNA, Ribosomal / genetics
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • Culture Media
  • DNA, Fungal
  • DNA, Ribosomal
  • DNA, Ribosomal Spacer
  • RNA, Ribosomal
  • RNA, ribosomal, 26S