In Vitro Susceptibility of Neisseria gonorrhoeae Strains to Mupirocin, an Antibiotic Reformulated for Parenteral Administration in Nanoliposomes

Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02377-17. doi: 10.1128/AAC.02377-17. Print 2018 Apr.

Abstract

Neisseria gonorrhoeae is an urgent antibiotic-resistant threat. This study determined the MICs of mupirocin to be 0.0039 to 0.0625 μg/ml for 94 N. gonorrhoeae strains. Cross-resistance with other antibiotics was not detected. Mupirocin, which is currently limited to topical administration, demonstrated activity by injection when delivered in nanoliposomes. The nanoliposomal formulation of mupirocin is a potential treatment for drug-resistant N. gonorrhoeae.

Keywords: Nano-mupirocin; antibiotic resistance; antimicrobial activity; antimicrobial resistance; cross-resistance; liposomes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Liposomes / chemistry*
  • Microbial Sensitivity Tests
  • Mupirocin / chemistry
  • Mupirocin / pharmacology*
  • Neisseria gonorrhoeae / drug effects*

Substances

  • Anti-Bacterial Agents
  • Liposomes
  • Mupirocin