Organocatalytic Stereoselective Synthesis of Fluorinated 3,3'-Linked Bisoxindoles

J Org Chem. 2018 Feb 2;83(3):1661-1666. doi: 10.1021/acs.joc.7b03084. Epub 2018 Jan 22.

Abstract

A highly diastereoselective organocatalytic method that produces 3-fluoro-3'-hydroxy-3,3'-bisoxindoles and the corresponding 3-fluoro-3'-amino derivatives having two adjacent chirality centers from fluorooxindoles and isatins in high yields is described. The reaction occurs in protic solvents at room temperature, it can be upscaled without compromising yield and stereoselectivity, and chromatographic product purification is not required.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Halogenation
  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Hydrocarbons, Fluorinated / chemistry
  • Indoles / chemistry*
  • Molecular Structure
  • Oxindoles
  • Stereoisomerism
  • Temperature

Substances

  • Hydrocarbons, Fluorinated
  • Indoles
  • Oxindoles
  • 2-oxindole