Role of Immune Status in Chemotherapy-Induced Transient Acantholytic Dermatosis

Skinmed. 2017 Dec 1;15(6):483-484. eCollection 2017.

Abstract

A 79-year-old man with a recent diagnosis of acute myeloblastic leukemia received induction chemotherapy with daunorubicin and cytarabine, plus moxifloxacin and fluconazole prophylaxis. Approximately 2 weeks later, an asymptomatic eruption appeared on his trunk. He then developed a neutropenic fever and was started on aztreonam, vancomycin, voriconazole, and amikacin and was transferred to our facility from an outside hospital. Micafungin was subsequently added, and the patient defervesced within a few days.

Publication types

  • Case Reports

MeSH terms

  • Acantholysis / chemically induced*
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Cytarabine / administration & dosage
  • Daunorubicin / administration & dosage
  • Drug Eruptions / etiology*
  • Humans
  • Ichthyosis / chemically induced*
  • Leukemia, Myeloid, Acute / drug therapy
  • Male

Substances

  • Cytarabine
  • Daunorubicin

Supplementary concepts

  • Grover's disease