Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

Kunal Malik; Emma Guttman-Yassky

doi:10.1016/j.jisp.2017.10.005

Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases

J Investig Dermatol Symp Proc. 2018 Jan;19(1):S62-S64. doi: 10.1016/j.jisp.2017.10.005.

Authors

Kunal Malik¹, Emma Guttman-Yassky²

Affiliations

¹ Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; College of Medicine, SUNY Downstate, New York, New York, USA.
² Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Department of Genetics and Genomics Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA; The Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: Emma.Guttman@mountsinai.org.

PMID: 29273110
DOI: 10.1016/j.jisp.2017.10.005

Abstract

Alopecia areata is a T-cell-mediated disease that shares phenotypic similarities with other inflammatory diseases, particularly atopic dermatitis, and lacks safe, effective, mechanism-specific treatments. Increasing data suggests that alopecia areata harbors contributions of T helper type 1, T helper type 2, T helper type 17/IL-23, and phosphodiesterase pathways. Antagonism of these axes is undergoing evaluation, and might elucidate the underlying molecular circuitry of alopecia areata, advancing the translational revolution for this disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Alopecia Areata / immunology*
Alopecia Areata / therapy*
Animals
Cytokines / antagonists & inhibitors*
Cytokines / immunology
Dermatitis / immunology
Dermatitis / therapy
Dermatitis, Atopic / immunology*
Dermatitis, Atopic / therapy*
Humans
Mice
Psoriasis / immunology
Psoriasis / therapy
Translational Research, Biomedical

Substances

Cytokines

Grants and funding

R13 AR071266/AR/NIAMS NIH HHS/United States